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KMID : 0613820100200111603
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Journal of Life Science
2010 Volume.20 No. 11 p.1603 ~ p.1610
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Effect of Fucus evanescens Fucoidan on Expression of Matrix Metalloproteinase-1 Promoter, mRNA, Protein and Signal Pathway
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Ku Mi-Jung
Jung Ji-Won
Lee Myeong-Sook
Cho Byung-Kyu
Lee Soon-Rye
Lee Hye-Sook
Olesya S. Vischuk
Tatyana N.Zvyagintseva
Svetlana P. Ermakova
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Abstract
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Fucoidans are sulfated fucosylated polymers from the cell wall of brown algae. We assessed the effects of Fucus evanescens fucoidan on ultraviolet-B (UVB)-induced expression of matrix metalloproteinase-1 (MMP-1) protein, mRNA, and promoter, and the phosphorylation of mitogen-activated protein kinases in vitro using an immortalized human keratinocyte cell line. Pretreatment with 10 and 100 ㎍/ml fucoidan significantly inhibited UVB-induced MMP-1 protein, mRNA and promoter activity, compared to UVB irradiation alone. Extracellular signal regulated kinase activation was markedly inhibited by treatment with fucoidan, though c-JUN N-terminal kinase activity and p38 activation were only marginally affected by fucoidan. F. evanescens fucoidan may be a potential therapeutic agent for the prevention and treatment of skin photoaging.
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KEYWORD
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Matrix metalloproteinase-1, fucoidan, ultraviolet B, photoaging, skin
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